Saliva kits for the recovery of DNA and RNA .
DNA Genotek‘s kits provide DNA and RNA in excellent quality and high yield. Other highlights include easy sample collection, safe handling and perfect stabilization of nucleic acids over weeks at room temperature. This makes transporting samples to the laboratory or study center safe and easy. DNA Genotek’s kits have also proven excellent for self-collection of samples by participants of studies.
Hard Facts .
By detecting minute genetic changes – single nucleotide polymorphisms (SNPs) – potential disease risks or pathological changes can be identified.
Reiner, J., Karger, L., Cohen, N., Mehta, L., Edelmann, L., & Scott, S. A. (2017). Chromosomal Microarray Detection of Constitutional Copy Number Variation Using Saliva DNA. The Journal of Molecular Diagnostics, 19(3), 397-403. https://doi.org/10.1016/j.jmoldx.2016.11.006
Kushner, S. C., Herzhoff, K., Vrshek-Schallhorn, S., & Tackett, J. L. (2018). Depression in early adolescence: Contributions from relational aggression and variation in the oxytocin receptor gene. Aggressive Behavior, 44(1), 60-68. https://doi.org/10.1002/ab.21724
Human DNA obtained with Oragene saliva kits is ideal for studying epigenetic changes.
Rushing, A., Sommer, E. C., Zhao, S., Po’e, E. K., & Barkin, S. L. (2020). Salivary epigenetic biomarkers as predictors of emerging childhood obesity. BMC Medical Genetics, 21(1), 34. https://doi.org/10.1186/s12881-020-0968-7
The excellent stabilization of DNA in the ORAgene Saliva Kits offers best conditions for telomere length determination.
Goldman, E. A., Eick, G. N., Compton, D., Kowal, P., Snodgrass, J. J., Eisenberg, D. T. A., & Sterner, K. N. (2018). Evaluating minimally invasive sample collection methods for telomere length measurement. American Journal of Human Biology, 30(1), e23062. https://doi.org/10.1002/ajhb.23062
Traditionally, bone marrow donor registries and transplant centers collect DNA samples from potential donors through either a blood sample or buccal swab. In contrast, sample collection with ORAgene kits is non-invasive and still provides high quality DNA for HLA typing.
DNA Genotek. (n.d.). HLA typing using DNA from oral samples collected with ORAcollect®-DNA. https://www. dnagenotek.com/ROW/pdf/PD-WP-00026.pdf
Epidemiological studies – e.g. on the incidence of type 2 diabetes mellitus in the population – require easy sample collection in order to achieve a high willingness to donate on the part of the subjects.
James, G., McMullin, M. F., Duncombe, A. S., Clarke, M., & Anderson, L. A. (2018). The MOSAICC study: Assessing feasibility for biological sample collection in epidemiology studies and comparison of DNA yields from saliva and whole blood samples. Annals of Human Genetics, 82(2), 114-118. https://doi.org/10.1111/ahg.12227
McElfish, P. A., Narcisse, M.-R., Long, C. R., Ayers, B. L., Hawley, N. L., Aitaoto, N., Riklon, S., Su, L. J., Ima, S. Z., Wilmoth, R. O., Schulz, T. K., & Kadlubar, S. (2017). Leveraging community-based participatory research capacity to recruit Pacific Islanders into a genetics study. Journal of Community Genetics, 8(4), 283-291. https://doi.org/10.1007/s12687-017-0313-9
Genetic analyses help to individualize a patient’s therapy.
Various kits for sampling from saliva .
ORAgene Saliva Kits .
DNA kits for research – versatile in use.