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Saliva kits for the recovery of DNA and RNA .

DNA Genotek‘s kits provide DNA and RNA in excellent quality and high yield. Other highlights include easy sample collection, safe handling and perfect stabilization of nucleic acids over days and weeks at room temperature. This makes transporting samples to the laboratory or study center safe and easy. DNA Genotek’s kits have also proven excellent for collecting samples from study participants at home (self-collection).

Hard Facts .

Applications .

By detecting minute genetic changes – single nucleotide polymorphisms (SNPs) – potential disease risks or pathological changes can be identified.

Reiner, J., Karger, L., Cohen, N., Mehta, L., Edelmann, L., & Scott, S. A. (2017). Chromosomal Microarray Detection of Constitutional Copy Number Variation Using Saliva DNA. The Journal of Molecular Diagnostics, 19(3), 397-403. https://doi.org/10.1016/j.jmoldx.2016.11.006

Kushner, S. C., Herzhoff, K., Vrshek-Schallhorn, S., & Tackett, J. L. (2018). Depression in early adolescence: Contributions from relational aggression and variation in the oxytocin receptor gene. Aggressive Behavior, 44(1), 60-68. https://doi.org/10.1002/ab.21724

Human DNA obtained with Oragene saliva kits is ideal for studying epigenetic changes.

Rushing, A., Sommer, E. C., Zhao, S., Po’e, E. K., & Barkin, S. L. (2020). Salivary epigenetic biomarkers as predictors of emerging childhood obesity. BMC Medical Genetics, 21(1), 34. https://doi.org/10.1186/s12881-020-0968-7

The excellent stabilization of DNA in the ORAgene Saliva Kits offers best conditions for telomere length determination.

Goldman, E. A., Eick, G. N., Compton, D., Kowal, P., Snodgrass, J. J., Eisenberg, D. T. A., & Sterner, K. N. (2018). Evaluating minimally invasive sample collection methods for telomere length measurement. American Journal of Human Biology, 30(1), e23062. https://doi.org/10.1002/ajhb.23062

Traditionally, bone marrow donor registries and transplant centers collect DNA samples from potential donors through either a blood sample or buccal swab. In contrast, sample collection with ORAgene kits is non-invasive and still provides high quality DNA for HLA typing.

DNA Genotek. (n.d.). HLA typing using DNA from oral samples collected with ORAcollect®-DNA. https://www. dnagenotek.com/ROW/pdf/PD-WP-00026.pdf

Epidemiological studies – e.g. on the incidence of type 2 diabetes mellitus in the population – require easy sample collection in order to achieve a high willingness to donate on the part of the subjects.

James, G., McMullin, M. F., Duncombe, A. S., Clarke, M., & Anderson, L. A. (2018). The MOSAICC study: Assessing feasibility for biological sample collection in epidemiology studies and comparison of DNA yields from saliva and whole blood samples. Annals of Human Genetics, 82(2), 114-118. https://doi.org/10.1111/ahg.12227

McElfish, P. A., Narcisse, M.-R., Long, C. R., Ayers, B. L., Hawley, N. L., Aitaoto, N., Riklon, S., Su, L. J., Ima, S. Z., Wilmoth, R. O., Schulz, T. K., & Kadlubar, S. (2017). Leveraging community-based participatory research capacity to recruit Pacific Islanders into a genetics study. Journal of Community Genetics, 8(4), 283-291. https://doi.org/10.1007/s12687-017-0313-9

Genetic analyses help to individualize a patient’s therapy.

Details .

Various kits for sampling from saliva .

Kit Artikelnummer Speichel-menge Swab-Format DNA/RNA Ausbeute Pädiatrische Verwendung Probenhaltbarkeit bei RT
OG-600 2 ml Nein DNA 110 µg Nein > 5 Jahre [2]
OG-610 1 ml Nein DNA 55 µg Nein > 5 Jahre [2]
ON-600 0,5 ml Nein DNA 12 µg [1] Nein Monate
OG-675 0,75 ml Ja DNA 17,3 µg [4] Ja > 5 Jahre [2]
OC-175 Ja DNA 2 µg Ja > 1 Jahr
OCR-100 Ja DNA 3,9 µg [3] Ja Monate
ORE-100 Ja RNA NA Ja < 60 Tage
[1] Iwasiow, R.M., Tayeb, M.A. and James, C.M.P. (2009). Quality, yield and bacterial content of DNA from human saliva collected and purified using Oragene•ONE. DNA Genotek. PD-WP-013.
[2] Iwasiow, R.M.; Desbois, A.; Birnboim, H.C. (2011). Long-term stability of DNA from saliva samples stored in the Oragene® self-collection kit. DNA Genotek. PD-WP-005.
[3] Panford-Walsh, R.; Doukhanine, E.; Bouevitch, A. (2012). Comparison of DNA from samples collected using ORAcollect®•DNA (OCR‑100) vs. buccal swabs. DNA Genotek. PD-WP-0021.
[4] Niles, J.O., Rabuka, S., and Iwasiow, R.M. (2010). Non-invasive, assisted collection of high quantity and quality genomic DNA from saliva of young children. DNA Genotek. PD-WP-018.

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ORAgene Saliva Kits .

DNA kits for research – versatile in use.

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